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Buy Gonadorelin Peptide (Gonadotropin Releasing Hormone (GNRH)).
Peptide hormone Gonadotropin-releasing hormone (GnRH; or also known as Luteinizing hormone-heleasing hormone (LHRH)) is an agonist of the Gonadotropin-releasing hormone receptor (GnRHR; LHRHR). The international non-proprietary name for Gonadotropin-releasing hormone pharmaceutical form is Gonadorelin; and this medication is a form of the endogenous GnRH and is identical to it in chemical structure. Gonadorelin was first synthesized in 1977, and for his clarification Roger Gullemin and Andrew V. Schall received the Nobel Prize.
The molecule is produced by neuroendocrine cells within the hypothalamus. It is considered to be a neuronal hormone because it is produced by certain nerve cells. The key area for the production of GnRH is The hypothalamic preoptic area (POA), which contains most of the GnRH secreting neurons. Similar to GH (growth hormone) secretion, Gonadorelin is also secreted pulsatilely. GnRH induces the release of gonadotropins Luteinizing hormone (LH) and Follicle-stimulating hormone (FSH) from the anterior pituitary, and its release is the first step in the system of functioning of the hypothalamo-pituitary-gonadial axis, resulting in a significant increase in testosterone blood levels in males.
Gonadorelin chemical structure
After secretion from the GnRH secreting neurons in The hypothalamic preoptic area, the molecule is transported by the blood via the hypothalamic-pituitary-gonadial axis to the pituitary gland, which contains gonadotropic cells, with GnRH responsive receptors – a seven-transmembrane G-protein-coupled receptor named Gonadotropin releasing hormone receptor (GnRHR).
The binding of the molecule to GnRHR subsequently activates in the pituitary gland the synthesis and secretion of gonadotropins – luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These processes are controlled by the size and frequency of GnRH pulses, as well as by feedback from androgens and estrogens. Low-frequency GnRH pulses lead to FSH secretion, while high GnRH pulses stimulate LH release. GnRH is degraded by proteolysis within a few minutes.
Peptides Prefer the Cold
Keep peptide vials refrigerated at all times to reduce peptide bond breakdown. DO NOT FREEZE. Most peptides, especially shorter ones, can be preserved for weeks if careful.
Always swab the top of the vial with an alcohol wipe, rubbing alcohol or 95% ethanol before use.
Before drawing solution from any dissolved peptide vial, fill the pin with air to the same measurement you will be filling with solution, ie. if you plan to take 0.1 ml, first fill the pin with 0.1ml of air, push the air into the vial, and then draw the peptide back up to the 0.1 ml marker. Doing so will maintain even pressure in the vial. Always remember to remove air bubbles from the pin by flicking it gently, needle side up, and pushing bubbles out. In addition, push out a tiny amount of solution to ensure there is no air left in the metal tip.
Only Mix With Sterile Bacteriostatic Water
The purity and sterility of bacteriostatic water are essential to prevent contamination and to preserve the shelf-life of dissolved peptides.
Push the pin through the rubber stopper at a slight angle, so that you inject the bacteriostatic water toward the inside wall of the vial, not directly onto the powder.
Lyophilized peptide should be stored at -20°C (freezer), and the reconstituted peptide solution at 4°C (refrigerated). Do not freeze once reconstituted.
Do Not Shake Vial To Mix
Air bubbles are unfavorable to the stability of proteins.