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TRIPTORELIN (GnRH) (2mg)

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Buy Triptorelin for sale online from Alpha Labs

FORM: 2mg/vial.

Buy Triptorelin Peptide  (Gonadotropin Releasing Hormone (GnRH)).

Decapeptide Triptorelin ((D-Trp6)-GnRH)) acts as an agonist analog of endogenous peptide hormone Gonadotropin-releasing hormone (GnRH), thus reversibly repressing of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). It is a potent GnRH receptor agonist. After chronic, continuous administration, Triptorelin effects sustained decreases in LH and FSH production and testicular and ovarian steroidogenesis.

Animal studies comparing triptorelin to native GnRH found that triptorelin had 13 fold higher releasing activity for luteinizing hormone, and 21-fold higher releasing activity for follicle-stimulating hormone.

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Triptorelin chemical structure

After secretion from the GnRH secreting neurons in The hypothalamic preoptic area, GnRH is transported by the blood via the hypothalamic-pituitary-gonadial axis to the pituitary gland, which contains gonadotropic cells, with GnRH responsive receptors – a seven-transmembrane G-protein-coupled receptor named Gonadotropin releasing hormone receptor (GnRHR). The binding of GnRH to GnRHR subsequently activates in the pituitary gland the synthesis and secretion of gonadotropins – luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

These processes are controlled by the size and frequency of GnRH pulses, as well as by feedback from androgens and estrogens. Low-frequency GnRH pulses lead to FSH secretion, while high GnRH pulses stimulate LH release. GnRH is degraded by proteolysis within a few minutes.

There are differences in GnRH secretion between females and males. In males, GnRH is secreted in pulses at a constant frequency; however, in females, the frequency of the pulses varies during the menstrual cycle, and there is a large surge of GnRH just before ovulation. GnRH secretion is pulsatile in all vertebrates, and is necessary for correct reproductive function.

Thus, a single hormone, GnRH1, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male. GnRH also affects various sexual behaviors. Elevated GnRH levels lead to increased libido and sexual activity in women. In men, an increase in GnRH induces a sharp increase in testosterone levels, accompanied by all of its typical strong anabolic and androgenic effects.

Triptorelin binds to Gonadotropin releasing hormone receptor (GnRHR) in the pituitary gland and stimulates secretion of gonadotrophins – Luteinzing hormone and Follicle-stimulating hormone. This causes an initial phase of LH and FSH stimulation, prior to down-regulation of the gonadotrophin-releasing hormone receptors, thereby reducing the release of gonadotrophins in the long term, which in turn leads to the inhibition of androgen and estrogen production. The effects of triptorelin can usually be reversed once the drug is discontinued.

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Peptides Prefer the Cold

Keep peptide vials refrigerated at all times to reduce peptide bond breakdown. DO NOT FREEZE. Most peptides, especially shorter ones, can be preserved for weeks if careful.

Always swab the top of the vial with an alcohol wipe, rubbing alcohol or 95% ethanol before use.

Before drawing solution from any dissolved peptide vial, fill the pin with air to the same measurement you will be filling with solution, ie. if you plan to take 0.1 ml, first fill the pin with 0.1ml of air, push the air into the vial, and then draw the peptide back up to the 0.1 ml marker. Doing so will maintain even pressure in the vial. Always remember to remove air bubbles from the pin by flicking it gently, needle side up, and pushing bubbles out. In addition, push out a tiny amount of solution to ensure there is no air left in the metal tip.

 

Only Mix With Sterile Bacteriostatic Water

The purity and sterility of bacteriostatic water are essential to prevent contamination and to preserve the shelf-life of dissolved peptides.

Push the pin through the rubber stopper at a slight angle, so that you inject the bacteriostatic water toward the inside wall of the vial, not directly onto the powder.

Lyophilized peptide should be stored at -20°C (freezer), and the reconstituted peptide solution at 4°C (refrigerated). Do not freeze once reconstituted.

 

Do Not Shake Vial To Mix

Air bubbles are unfavorable to the stability of proteins.

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Additional information

Sequence

Glu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2

Appearance

White Lyophilized Powder

Specification

2mg/vial

CAS

57773-63-4

Molecular Formula

C64H82N18O13

Molecular Weight

1,311.5 g/mol