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IPAMORELIN (5mg)

$49.99

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Buy Ipamorelin for sale online from Alpha Labs

FORM: 5mg/vial.

Buy Ipamorelin Peptide (Growth Hormone Releasing Peptide).

Ipamorelin (Aib-His-D-2-Nal-D-Phe-Lys-NH2) is a synthetic pentapeptide which has distinct and specific growth hormone (GH)-releasing properties. It’s amino acid sequence is Aib-His-D-2-Nal-D-Phe-Lys-NH2 that was derived from GHRP-1.

Ipamorelin triggers and stimulates Growth hormone production by mimicking the action of the natural hormone Ghrelin: In the hypothalamus binds to Ghrelin receptors), stimulates the release of Somatocrinin (also called as Growth hormone releasing hormone – GHRH) and at the same time it inhibits the amount of Somatostatin and suppresses its action.  In addition, it stimulates body weight gain in animals. Like pralmorelin and GHRP-6, ipamorelin does not affect prolactinfollicle-stimulating hormone (FSH), luteinizing hormone (LH), or thyroid-stimulating hormone (TSH) levels. However, unlike pralmorelin (GHRP-2) and GHRP-6, but similarly to GHRH, ipamorelin does not stimulate the secretion of adrenocorticotropic hormone (ACTH) or cortisol, and is highly selective for inducing the secretion only of GH.

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Ipamorelin chemical structure

Ipamorelin released GH from primary rat pituitary cells with a potency and efficacy similar to GHRP-6 (ECs) = 1.3+/-0.4nmol/l and Emax = 85+/-5% vs 2.2+/-0.3nmol/l and 100%). A pharmacological profiling using GHRP and growth hormone-releasing hormone (GHRH) antagonists clearly demonstrated that Ipamorelin, like GHRP-6, stimulates GH release via a GHRP-like receptor.

In pentobarbital anaesthetised rats, Ipamorelin released GH with a potency and efficacy comparable to GHRP-6 (ED50 = 80+/-42nmol/kg and Emax = 1545+/-250ng GH/ml vs 115+/-36nmol/kg and 1167+/-120ng GH/ml). In conscious swine, Ipamorelin released GH with an ED50 = 2.3+/-0.03 nmol/kg and an Emax = 65+/-0.2 ng GH/ml plasma. Again, this was very similar to GHRP-6 (ED50 = 3.9+/-1.4 nmol/kg and Emax = 74+/-7ng GH/ml plasma). GHRP-2 displayed higher potency but lower efficacy (ED50 = 0.6 nmol/kg and Emax = 56+/-6 ng GH/ml plasma).

The specificity for GH release was studied in swine. None of the GH secretagogues tested affected FSH, LH, PRL or TSH plasma levels. Administration of both GHRP-6 and GHRP-2 resulted in increased plasma levels of ACTH and cortisol. Very surprisingly, Ipamorelin did not release ACTH or cortisol in levels significantly different from those observed following GHRH stimulation. This lack of effect on ACTH and cortisol plasma levels was evident even at doses more than 200-fold higher than the ED50 for GH release. In conclusion, Ipamorelin is the first GHRP-receptor agonist with a selectivity for GH release similar to that displayed by GHRH.

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Peptides Prefer the Cold

Keep peptide vials refrigerated at all times to reduce peptide bond breakdown. DO NOT FREEZE. Most peptides, especially shorter ones, can be preserved for weeks if careful.

Always swab the top of the vial with an alcohol wipe, rubbing alcohol or 95% ethanol before use.

Before drawing solution from any dissolved peptide vial, fill the pin with air to the same measurement you will be filling with solution, ie. if you plan to take 0.1 ml, first fill the pin with 0.1ml of air, push the air into the vial, and then draw the peptide back up to the 0.1 ml marker. Doing so will maintain even pressure in the vial. Always remember to remove air bubbles from the pin by flicking it gently, needle side up, and pushing bubbles out. In addition, push out a tiny amount of solution to ensure there is no air left in the metal tip.

 

Only Mix With Sterile Bacteriostatic Water

The purity and sterility of bacteriostatic water are essential to prevent contamination and to preserve the shelf-life of dissolved peptides.

Push the pin through the rubber stopper at a slight angle, so that you inject the bacteriostatic water toward the inside wall of the vial, not directly onto the powder.

Lyophilized peptide should be stored at -20°C (freezer), and the reconstituted peptide solution at 4°C (refrigerated). Do not freeze once reconstituted.

 

Do Not Shake Vial To Mix

Air bubbles are unfavorable to the stability of proteins.

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Additional information

Sequence

Aib-His-D-2-Nal-D-Phe-Lys-NH2

Appearance

White Lyophilized Powder

Specification

5mg/vial

CAS

170851-70-4

Molecular Formula

C38H49N9O5

Molecular Weight

711.9 g/mol